3d design program inventor 2022 Search Results


93
cell applications inc 102-3d
102 3d, supplied by cell applications inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
102-3d - by Bioz Stars, 2026-07
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Oxford Instruments 3d surface rendering reconstructions
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
3d Surface Rendering Reconstructions, supplied by Oxford Instruments, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/3d+design+program+inventor+2022/bio_rxiv__2022__08__10__503440-77-34-38?v=Oxford+Instruments
Average 99 stars, based on 1 article reviews
3d surface rendering reconstructions - by Bioz Stars, 2026-07
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90
SolidWorks Corp cad software (2022 sp2.0 professional version
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Cad Software (2022 Sp2.0 Professional Version, supplied by SolidWorks Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/3d+design+program+inventor+2022/pm37893266-4-8-7?v=SolidWorks+Corp
Average 90 stars, based on 1 article reviews
cad software (2022 sp2.0 professional version - by Bioz Stars, 2026-07
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86
Geomagic Inc metrology grade 3d analysis software program
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Metrology Grade 3d Analysis Software Program, supplied by Geomagic Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
metrology grade 3d analysis software program - by Bioz Stars, 2026-07
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90
InfoMax Inc 3d infomax
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
3d Infomax, supplied by InfoMax Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ANSYS inc workbench 2022 r1
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Workbench 2022 R1, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
Geomagic Inc control x 2022 3d superimposition software
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Control X 2022 3d Superimposition Software, supplied by Geomagic Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ANSYS inc full-wave 3d finite element method simulator ansys hfss 2022 r1
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Full Wave 3d Finite Element Method Simulator Ansys Hfss 2022 R1, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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full-wave 3d finite element method simulator ansys hfss 2022 r1 - by Bioz Stars, 2026-07
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Merck KGaA magnetic milliplex map antibody-conjugated beads
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Magnetic Milliplex Map Antibody Conjugated Beads, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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magnetic milliplex map antibody-conjugated beads - by Bioz Stars, 2026-07
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Siemens AG 3d cad software solid edge 2022
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
3d Cad Software Solid Edge 2022, supplied by Siemens AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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3d cad software solid edge 2022 - by Bioz Stars, 2026-07
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86
Abaqus Inc fem software package named abaqus 2022 version
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Fem Software Package Named Abaqus 2022 Version, supplied by Abaqus Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fem software package named abaqus 2022 version - by Bioz Stars, 2026-07
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Drummond Scientific nanoject ii
NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in <t>3D</t> <t>surface-reconstruction</t> of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain
Nanoject Ii, supplied by Drummond Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in 3D surface-reconstruction of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain

Journal: bioRxiv

Article Title: Cortical distribution of neurofilaments associates with pathological hallmarks and MRI measures of atrophy and diffusivity in Parkinson’s disease

doi: 10.1101/2022.08.10.503440

Figure Lengend Snippet: NfL accumulation and fragmentation, and loss of neurofilament colocalization in PD and PDD/DLB. Maximum projections (z-stacks n=6 μm) of fluorescence stainings of NfL (red) and p-NfM/H (green) together with DAPI (blue) in the parahippocampal gyrus of a representative control ( left , control number 10 in Supplementary Table 1, online resource 1), PD ( middle , PD number 3 in Supplementary Table 1, online resource 1) and PDD/DLB ( right , here a DLB donor, PDD/DLB number 12 in Supplementary Table 1, online resource 1) are shown. a , b , and c show the difference in NfL staining pattern in control, PD and PDD/DLB, respectively. NfL was markedly accumulated in neuronal somas and proximal axons in PDD/DLB cases, reflecting the higher NfL immunoreactivity described quantitatively in . High NfL immunoreactivity was found in neuronal somas showing neurodegenerative morphological features, such as c neurons with nuclear fragmentation and swelling (*), and d corkscrew (**) and ballooned (***) appearances (panel d shows a zoom-in 3D surface-reconstruction of neurodegenerative neurons). Moreover, c NfL accumulation was also identified in a proximal axon showing fragmentation (arrow), closely tighten by a glial cell (#); e shows the zoom-in 3D surface-reconstruction of the white square in c , showing axonal fragmented morphology (arrow) and a glial cell wrapping the degenerating axon (#). f , g and h show the colocalization (yellow) of NfL and p-NfM/H in control, PD and PDD/DLB, respectively, which was reduced in PD and PDD/DLB. Moreover, accumulation and fragmentation of NfL staining patterns were observed in several axons, where g NfL seemed to fragment within a p-NfM/H axon in PD (dashed arrow) and h axonal swellings intermitted axonal fragmentations in PDD/DLB (arrows). i shows the zoom-in 3D surface-reconstruction of the white square in h , clearly showing fragmentation of the NfL positive axon (arrows). Legend: DLB: Dementia with Lewy Bodies; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain

Article Snippet: After scanning, the images were deconvoluted using CMLE algorithms in Huygens Professional (Scientific Volume imaging; Huygens, The Netherlands; https://svi.nl/Huygens-Professional ), and their maximum projections (ImageJ Fiji, National Institute of Health USA; https://imagej.nih.gov/ij/ ) or 3D surface rendering reconstructions (Imaris, Oxford instruments 2022: https://imaris.oxinst.com/ ) were used to represent graphically the structures of interests and their morphologies.

Techniques: Fluorescence, Control, Staining